Rat microglia grown in tissue culture in green, along with nerve fiber processes shown in red. © Gary Shaw - wikipedia.org

German researchers have tracked down the causes for central nervous system side effects of cancer immunotherapies and blocked them in small animal models.

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In the rapidly evolving healthcare landscape, the concept of 4P Medicine—Prevention, Prediction, Precision, and Participation—marks a transformative shift towards personalized healthcare. This approach, refined over the last 15 years, aims to revolutionize how we understand, prevent, and treat diseases by focusing on each patient’s unique needs. The recent whitepaper by Worldwide Clinical Trials highlights the profound impact of 4P Medicine on clinical development and patient care.

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A print magazine focussing on start-ups in the life sciences! Like a catalyst, it aims to promote young companies in the life sciences with the right impulses.

Misfolded protein accumulation and evidence of ISR activationis present in multiple neurological conditions. © BMS and Hetz et al, Nat Rev – Neur 2017

Evotec SE has reached a predefined milestone worth €20m in the CRO’s partnership with Bristol Myers Squibb (BMS).

CEO Dr Peter Sondermann © Tacalyx GmbH

Glycan target specialist Tacalyx GmbH expands its seed financing to €14m to advance its anti-TACA cancer therapies.

PAS amd CD3 staining of renal tissue at day 10 (scale bars, 10 μm). © Leon U. B. Enk

Researchers at University Hospital Hamburg-Eppendorf have laid the foundation to screen for molecules that shift Th17 cells from proinflammatory or immune-dampening mode.
 

© Elsie Biotechnology

GSK takes over Elsie Biotechnologies in US$50m deal to boost its oligonucleotide-based drug platform and pipeline.

Lu 177-dotatate (pink and orange) binds to somatostatin receptors (green) on neuroendocrine tumor cells (blue) and kills the cells through the release of radioactive  particles.@ NCI. Credit: Adapted from Frontiers in Oncology. January 2019. Front. Oncol. doi: 10.3389/fonc.201800663

ITM Isotope Technologies Munich SE has raised €188m ito boost radiopharma pipeline, contract manufacturing cpacity, and launch ITM-11.

Quantro used thiol(SH)-linked alkylation for the metabolic sequencing of RNA (SLAM seq), an orthogonal-chemistry-based RNA sequencing technology that detects 4-thiouridine (s4U) incorporation in RNA species at single-nucleotide resolution, to measure RNA-polymerase-II-dependent gene expression dynamics. © QUANTRO Therapeutics GmbH

Viennese biotech QUANTRO Therapeutics identifies small molecule targeting an onkogenic transcription factor in Boehringer Ingelheim collab.

Picture: SynaptixBio

 At the end of May, Dr Uwe Meya took over as Chief Medical Officer at Oxford-based SynaptixBio.