Why are so many vaccine developers choosing Thermo Scientific Charged Aerosol Detection (CAD)? Hear the third very good reasons why CAD was used for analysis of lipid nanoparticles in approved mRNA vaccines.
Nanobodies are emerging as important tools for tumor diagnosis and treatment due to their small size, simple humanization, low immunogenicity, superior affinity and stability, high penetration, and adequate levels of solubility, and are expected to revolutionize the antibody-based drug therapy. In 2018, the worlds first nanobody was approved for marketing in the European Union to treat adult patients with acquired thrombotic thrombocytopenic purpura. At present, more than 20 nanobodies are being tested in clinical research worldwide, mostly in clinical phase I or II.
Since the approval of Orthoclone OKT3 in 1986, more than 100 monoclonal antibodies (mAbs) have been approved by the Food and Drug Administration (FDA) to treat a variety of diseases ranging from autoimmune disorders, infectious diseases, and cancer [1-2]. In the context of the current COVID-19 pandemic, its crucial that these biologics are developed rapidly and efficiently. Among various antibody discovery approaches, including hybridoma technology, single B cell screening is a powerful and efficient strategy for generating antigen-specific mAbs based on the direct amplification of the VH and VL regions encoding genes from single B cells [3-4]. Notably, single B cell screening has various advantages that include maintaining the naïve VH/VL pairing, requiring relatively few cells, and the ability to discover antibodies against challenging targets.
ACHEMA is the world forum and leading trade show for the chemical, pharmaceutical and food industries. It’s where new developments are unveiled and trends are discussed.
Successful restart: From 31 May to 1 June 2022, Chemspec Europe attracted 5,122 industry experts from 57 countries, of which 3,162 were trade visitors. A total of 287 exhibitors from 26 countries presented their product portfolio on a net exhibition space of 5,300 m2 at Messe Frankfurt, Germany. With topics such as sustainable innovations, regulatory compliances, circular bio-economy, green chemistry, digitalisation, and the flourishing startup scene, the 35th International Exhibition for Fine and Speciality Chemicals highlighted insights of current and future developments within the industry.
Amidst the rapid evolution of DNA sequencing technologies in past years, the industry has been working tirelessly to make genomics more accessible. Since the Human Genome Project, which saw scientists from six countries coming together to map the first human genome at nearly $3 billion over 13 years, the cost of whole-genome sequencing has fallen to less than $1,000 today. Yet, the quest to produce larger amounts of short- and long-read data in a shorter span of time and at an even lower cost continues.
The optically pumped semiconductor laser (OPSL) is an ideal light source for structured illumination microscopy (SIM), a laser fluorescence technique that can deliver unique information in drug discovery.
The rapid growth of active pharmaceutical ingredients (APIs) has led to more biotech companies enlisting the support of strategic partners to navigate the regulatory environment and bring their innovative products to market.
The 12th edition of the European Biotechnology Science & Industry Guide once more offers an interesting cross-section of the European biotech scene.