Operational Strength of Richter-Helm /picture: ©Richter-Helm

CDMO Continuous growth and diversification of the biotechnology market for pharmaceutical production have been recorded in the past years. It is expected that both trends, growth and diversification from blockbusters towards niche products, will continue. What requirements are derived from customers’ point of view and what are the advantages of Richter-Helm as a successful CDMO to fulfil such needs?

96-well EchoLUTION ultra-fast RNA/DNA extraction - flowchart. Just one centrifugation step is required to obtain highly pure inhibitor-free nucleic acid (left and right). If extracting viral RNA for, e. g., SARS-CoV-2 tests, the processing time is reduced to only 2 minutes (left). For purification of genomic DNA from various materials, the time varies from 10 to 30 minutes (right). Bioecho recently received the award „innovative through research. Picture: BioEcho

BioEcho develops single-spin and 96/384-well kits based on the patent pending single-step EchoLUTION nucleic acid extraction process. Highly superior to the commonly used silica-based solutions (bind-wash-elute), the isolated inhibitor-free RNA/DNA is detected with increased sensitivity. Furthermore, the whole procedure is up to 20-fold faster: Washing steps are not required, saving time, costs and plastic waste. Due to the expertise of its founders and employees, BioEcho also uses its know-how to support diagnostic or pharma companies with specialized scientific knowledge. Especially in times like these, BioEcho helps to accelerate accurate tests on certain RNA/DNA viruses such as SARS-CoV-2.

picture: sea and sun/stock.adobe.com

Clinical Trails With the end of the Brexit transition period on 31 December 2020, the known conditions will change and pharmaceutical companies not prepared will face serious issues and uncertainties. No extension of the transition period has been requested, and according to a joint technical notice by the European Commission, EMA and HMA, no further prolongation beyond 2020 is possible. EU pharmaceutical law will no longer apply for the UK.

Targeted Radionuclide Therapy uses radiopharmaceuticals, which are conjugates of a medical radioisotope and a tumour-specific targeting molecule, recognising the tumour cell precisely according to the lock-and-key principle.
Picture: ITM Isotopen Technologien München AG

Precision Oncology High-Precision Radionuclide Therapy is a promising, new generation of targeted molecular therapy in which the smallest amounts of medical radioactivity find their way through the bloodstream specifically to the tumour cells for diagnosis and treatment of cancer.

High-quality cell culture inserts of the new brand cellQART® can now also be purchased directly from the German manufacturer SABEU.

Picture: Sino Biological

Sino Biological is a world-leading manufacturer of recombinant protein and antibody reagents for life science researches and drug discoveries. In response to the current COVID-19 pandemic, we have developed a series of active reagents (virus proteins, antibodies, and pseudoviruses) to facilitate serologic tests and anti-viral drug developments.

©AiCuris Anti-infective Cures

Emperor Nero, reportedly, fiddled as Rome burned in 64 A.D., much like society for a long time ignored and repressed the pending crisis of antimicrobial resistance (AMR).

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Gene therapy, considered to be the most efficient and sometimes only treatment option for many severe and life-threatening diseases, is shifting to more common indications with higher numbers of patients including Parkinson’s and Alzheimer’s disease. This is where the new ELEVECTA® AAV producer cell lines come into play. ELEVECTA® is a revolutionary technology that enables viral vector manufacturing in an industry-standard, scalable suspension format.

Abb.: Tosoh

Chromatography methods and practical tips to simplify and reduce the costs of your processes

96-well EchoLUTION RNA/DNA extraction - flowchart. Just one centrifugation step is required to obtain highly pure inhibitor-free nucleic acid. If throat swabs are stored in a denaturating buffer, the processing time for 96 samples is reduced to only 5 minutes. Bioecho recently received the award „innovative through research. Picture: BioEcho

BioEcho develops single-spin and 96/384-well kits based on the proprietary single-step EchoLUTION nucleic acid extraction process. Highly superior to the commonly used Silica-based solutions (bind-wash-elute), the whole procedure is extremely fast. Washing steps are not required and the isolated inhibitor-free RNA/DNA is detected with increased sensitivity. Due to the expertise of its founders and employees, BioEcho also uses their know-how to support companies with limited research capacities or specialized scientific knowledge. Especially in times like these, BioEcho helps to accelerate accurate tests on certain RNA/DNA viruses or pathogens.