Osteoarthritic knee vs normal knee. © BruceBlaus/wikimedia.com

Based on genetic data, a new diagnostic algorithm can differentiate between five different rheumatic diseases.

© ExScientia Ltd
Novo Holdings leads the current US$60m Series C round of ExScientia Ltd, the world-leading artificial intelligence (AI)-driven drug discovery company.
© Christian Trick/Pixabay.com

Metabolic disease specialist Poxel SA has announced a private placement of 2,358,483 new ordinary shares at €0.02 per share reserved to specified investors.

© Merck KGaA

Researchers at the University Oxford and AstraZeneca have started enrolment for a Phase II/III trial to test a COVID-19 vaccine in 10,000 volunteers.

© GBA Group Pharma

An international research consortium provides data demonstrating that SARS-CoV-2 antibody tests are only useful for population-based analyses.
 

Immunovative scientists working in clean rooms prepare the experimental drug AlloStim for use in human clinical trials. © Immunovative

Two companies have presented a novel vaccination concept that might protect risk groups from new SARS-CoV-2 variants.

© Abivax

French Abivax SA has received a €36m non-dilutive funding from Bpifrance for its ABX464 Covid-19 programme.

4Teen4's antibody procizumab might be a way not not only resueing patients with cardiogenic shock and burns from organ failure but also patients with other conditions caused by massive cell death such as COVID-19-triggered ARDS. © 4Teen4 Pharmaceuticals GmbH

4TEEN4 Pharmaceuticals GmbH published data suggesting that high plasma levels of dipeptidyl peptidase 3 were indicative for upcoming multiple organ failure in burn patients.

ACIB/Ionophore

The funding pot of the Innovation Medicines Initiative has been boosted to €117m. IMI has also selected eight projects to fund.

University of Goergia researchers have decribed the shielded versions of the viral S-protein. a. Side view (upper panels) and Top view (lower panels) of the SARS-CoV-2 S protein (grey surface) with homogeneous Complex glycosylation (magenta) showing aligned antibody fragments (ribbons) from co-complexes with the S glycoproteins from SARS-CoV-1 (orange) and MERS (cyan) 48,50-61 . b. Glycans present on SARS-CoV-2 S glycoprotein that are incompatible with known antibody positions due to steric overlap are shown in yellow. a. Side view (upper panels) of the SARS-CoV-2 S protein (grey) with homogeneous complex glycosylation (magenta) showing aligned antibody fragments (ribbons) from co-complexes with the S glycoproteins from SARS-CoV-1 (orange) and MERS (cyan). b. Glycans present on SARS-CoV-2 S glycoprotein that are incompatible with known antibody positions due to steric overlap are shown in yellow. c. Potential antibody poses after elimination of epitopes blocked by S protein glycosylation. © Doi: 10.1101/2020.04.07.030445

British researchers have deciphered the glycosylation pattern of the viral spike protein of SARS-CoV-2 laying the foundation for vaccine development.