Bicycles can be linked together as bi-specifics, which simultaneously bind to two different proteins to deliver dual pharmacology. © Bicycle Therapeutics plc

Roche AG‘s has paid US$30m upfront in a potential US$1.7bn deal to get access to Bicycle Therapeutics plc’s technology platform to target immune checkpoints.

ioNEURONS/glut express glutamatergic neuron-specific markers Copyright: Bit Bio

Widespread use of human induced pluripotent stem cell (hiPSC) derived mature cell types is restricted by complex differentiation protocols and inefficient reprogramming methods. By applying a novel gene engineering approach, opti-oxTM, to cellular reprogramming these restrictions have been largely overcome. This proprietary technology enables precise reprogramming and homogeneous differentiation of entire stem cell cultures into any desired cell type.

Microglia/macrophage  activated form from rat cortex after traumatic brain injury (lectin staining with HRP). © wikimedia/Grzegorz Wicher
Researchers at Trinity College in Dublin have demonstrated that resetting brain-specific immune cells improves traumatic brain injury (TBI) recovery.
 
Meeting of Mr Charles Michel, President of the European Council with Sebastian Kurz, Austrian Federal Chancellor; Mark Rutte, Dutch Prime Minister; and Mette Frederiksen, Danish Prime Minister (from left to right).
© European Union

Negotiations of the EU Council on the EU’s seven-year budget have failed, putting R&D funding at risk for significant cuts.

Glycom's €50m HMO manufacturing site in Esbjerg, Denmark. © Glycom A/S

Royal DSM NV has entered the growing market of human milk oligosaccharides (HMO) taking over the producer of recombinant 2′-fucosyl lactose, Danish Glycom A/S.

Immatics Biotechnologies has labs in Tübingen, Munich and Houston, US. © Immatics Biotechnologies GmbH

US-German immunooncology specialist Immatics Biotechnologies GmbH has licensed two of its TCR-T programs to GlaxoSmithKline for US$50m upfront.

Univercells SA

Univercells S.A. cashes in up to €50m from the KKR subsidiary Gamma Bioscience to advance its gene and cell therapy manufacturing platform.

© CDC

Shortly before a EU health ministers discuss the spread of the Chinese coronavirus, EU diagnostic labs have considered themselves prepared for a possible Sars-CoV-2 epidemic.

Co-founder Fiona Withey is the new Chief Executive Officer of TrakCel, a software developer of orchestration systems for advanced therapies. Co-founder Ravi Nalliah was appointed to the role of Chief Strategy Officer.

Applied Photophysics Limited, active in biophysical characterization of biomolecules, has appointed Tim Flanagan as Chief Executive Officer and member of the Board of Directors.