Sino Biological and BioGeometry Deepen Strategic Cooperation to Empower Protein R&D with Generative AI

Sino Biological is committed to driving innovation in biomanufacturing by integrating cutting-edge technologies. The company’s expertise in protein and antibody research, combined with BioGeometry’s breakthroughs in generative AI, offers unparalleled solutions for protein design and optimization. This partnership is set to significantly accelerate the pace of discovery for researchers and pharmaceutical companies, providing clients with access to faster, more efficient protein R&D services.

Deep learning, particularly large-scale generative AI models, is revolutionizing biomanufacturing. AlphaFold3, using diffusion models, can now predict biomolecule structures, significantly advancing protein design. BioGeometry, a leader in generative AI for protein design, pioneered diffusion models with its influential 2021 “GeoDiff” paper. In June, BioGeometry introduced GeoFlow, a protein foundation model that excels in structure prediction and design, rivaling AlphaFold3 in antigen-antibody complex prediction. Freely available for non-commercial use, GeoFlow is integrated into BioGeometry’s GeoBiologics platform, enhancing protein design efficiency with fewer experiments.

Sino Biological and BioGeometry partnership to combine generative AI with wet lab experiments, offers advanced research tools and CRO services. Their collaboration leverages BioGeometry’s GeoFlow-based platform and Sino Biological’s protein expression capabilities to improve design efficiency and accuracy. By updating AI models with experimental data, they accelerate project completion. They’ve already successfully developed nanobodies and enzymes and aim to further innovate AI-driven protein research, contributing to advancements in biopharmaceuticals, disease treatment, and sustainable development.

Sino Biological has long been recognized for its comprehensive CRO technical service platform, encompassing gene cloning, protein expression, antibody development, and quality control research. With capabilities that span from gene sequence to large-scale production, Sino Biological delivers preclinical production services at an unmatched speed, producing purified monoclonal antibodies in as little as a few weeks. The company’s vast protein and antibody library, along with its extensive screening and production platforms, positions Sino Biological as a global leader in life science research and innovative drug development.

Looking ahead, Sino Biological and BioGeometry will continue to explore new applications of AI in protein research and development, aiming to shape the future of biopharmaceutical R&D and make significant contributions to disease treatment and sustainable scientific progress.

About Sino Biological
Sino Biological is a global leader in protein and antibody research, specializing in the production of high-quality recombinant proteins and antibodies for life sciences research and innovative drug development. Headquartered in Beijing, Sino Biological was listed on the Shenzhen Stock Exchange’s ChiNext board in August 2021 (stock code: 301047). As a national high-tech enterprise, the company has developed five core technology platforms, advancing biological reagent research centered around proteins and antibodies. Sino Biological offers over 74,000 stocked products, including nearly 9,000 recombinant proteins, 14,000+ antibodies, 50,000 genes, and a series of high-performance serum-free media products. The company also operates a one-stop CRO service platform covering gene cloning, protein expression, antibody development, production, and quality control research. With its expertise, Sino Biological has successfully developed complex reagents, such as full-length membrane proteins, kinases, phosphorylated antibodies, and GMP-grade cytokines, establishing the world’s leading recombinant protein and antibody library based on human cell expression.

About BioGeometry
BioGeometry is a pioneering company in digital biology, focused on leveraging generative AI for protein design. Founded in 2022 by Prof. Jian Tang, with Turing Award laureate Yoshua Bengio as chief scientific advisor, BioGeometry is at the forefront of AI4Protein innovation. The company was one of the first to apply diffusion generative models to biomolecular structure modeling, and it developed GeoFlow, a groundbreaking protein foundation model. GeoFlow excels in both protein design and structural modeling. BioGeometry’s AI-driven biologics design platform (GeoBiologics) combined with its high-throughput wet-lab validation platform creates a closed-loop “design-build-test-learn” system, enabling highly accurate and efficient protein design and optimization for both biomedicine and synthetic biology.