Penny Owen

Like every sector of the UK economy, life sciences has been beset with uncertainty since the country voted to leave the European Union. Last week prime minister Theresa May finally gave us some clarity on her plans for Brexit, which will allow us to prepare for the future.

Actelion's business centre in Alschwil, Switzerland. © Actelion

Following a month-long take-over poker, J&J’s and Actelion’s boards have agreed to support an all-cash tender offer from J&J in which shareholders are set to receive US$280.08 per share and one share of NewCo, an R&D spin out to be led by Actelion CEO Paul Clozel. J&J will acquire at least 67% of Actelion’s shares and will hold 16% of NewCo with an option to further 16%.

Staff member of 4SC presenting the epigenetic cancer pill, resminostat. © 4SC

German 4SC AG’s epigenetic cancer drug resminostat is back. What seemed to be a flop after Phase II failure has being transformed into a success story of personalised medicine. By accurate data analysis 4SC’s partner Yakult Honsha identified a subgroup in which the drug significantly improved outcomes for patients with hepatocellular carcinoma (HCC).

Frédéric Gomez

The surprising election of Donald Trump as the next US President led to a spectacular comeback of biotech shares. The long-term prospects depend on Trump’s healthcare strategy and the (much-desired) return of generalist funds.

Aedes agyptii mosquito. Only blood-sucking female insects transmit viral pathogens when they bite.

Oxford-based Intrexion-subsidiary Oxitec plans to release male GM mosquitoes that produce nonviable offspring in India, in order to limit the spread of dengue and chikungunya fevers transmitted by Aedes aegyptii.

Berliner Klima Schulen 2015

Two biotech CEOs have been selected by the European Commission for the High Level Group. The EU think tank will provide strategic input to Horizon 2020 and a €2.5bn fund to support innovation by 2020 in order to boost disruptive technologies and to address gaps in in the current innovation support landscape. 

Mode of Action of Affimed's immune cell engager platform Tandab, exemplified on the company's lead candidate AFM 13. © Affimed NV

While German Nasdaq company Affimed (AFMD) had an accumulated loss of over €100m, an annual development cost of about €38m for its Tandab pipeline, and an income of only about €8m from collaborations at the end of 2015, the company is trying to bulk up its funds through a public offering of common stock. 

William Linton, © Promega

Promega-founder William Linton has been elected as a member of the Supervisory Board of lab supplier Eppendorf AG.

Belgian start-up company Octimet Oncology NV has secured €11.3m in a series A financing round. The funds will be used to develop two MET kinase blockers to treat solid tumours.

Photo: A third of US diabetics develop fibrosis in the course of diabetic nephropathy (see photo), several millions of US citizens suffer from liver fibrosis and about 100,000 have idiopathic lung fibrosis. © Wikipedia/KGH

Drug screening expert Evotec AG and Ontario-based MaRS Innovation have launched the joint venture company Fibrocor Therapeutics LP to tackle fibrosis, an unmet medical need and multi-billion US dollars market.