© 123rf.com/sangoiri

Swiss newco Arvelle Therapeutics has baged a $180m (€159.1m) series A financing led by LSP. The company licenced the anti-epileptic candidate cenobamate (YKP3089) for $100m (€88.4m) upfront from SK Biopharmaceuticals.

Plastics production from 1950 to 2017. © nova-institute

The market for bio-based building blocks and polymers showed moderate growth to 7.5 million tonnes in 2018 and will grow with a CGAR of 4% by 2023 reports German nova-Institute. 

Healthy (left) and type 1 diabetes (right) islet of Langerhans in the pancreas. ©  123rf.com/designua

Swiss researchers have demonstrated a way to cure type I diabetes without cell transplantation. In model mice the reprogrammed non-islet cells from human pancreas

Afyren's current preindustrial production plant.© Afyren

French industrial biotech company Afyren announced a capital increase of €21m in a financing round led by  Sofinnova Partners and Valquest Partners to scale up its biobased organic acid production to industrial scale.

© Biotech Campus Delft
Biotech Campus Delft, Royal DSM and YES!Delft partner up have launched a Biotech Validation Lab to validate the business concepts of European biotech startups.  
© 123rf.com/decade3d

Gene therapy uniQure NV (Amsterdam) reported that factor IX levels of patients with severe hemophilia B raised to a mean of 38% of normal 12 weeks after a single injection of AMT-061.

Suggested mode of action of OSE-127: Blocking of an epitope overlapping the
IL-7 binding domain and the receptor heterodimerization region prevents activation of JAK/STAT signaling as well as PI3K and Erk
signaling, which blocks inflammation by neutralisation of IFN-gamma producing antigen-specific memory T cells © Nature Communicationsvolume 9, Article number: 4483 (2018)

Ose Immunotherapeutics has got the first milestone payment within its €272m deal with Servier inked in 2016.

The montage shows representative confocal images of siCTL HUVEC cells used in Kugeratski et al. F-actin, in white, is stained with phalloidin, Cortactin is in yellow and DAPI in blue.
© Amelie Juin

Analyses of the stroma cell proteome have revealed how intratumoral hypoxia triggers the formation of dysfunctional blood vessels that block drugs from entering the tumour and push metastasis.  

© Jennewein Biotechnologie
Jennewein Biotechnologie and Asia’s largest dairy company Yili Group have joined forces to develop an innovative infant formula tailored to the Chinese market.
Regulation through orexin A and B. @ www.cell.com/https://doi.org/10.1016/j.tem.2016.06.011

Sosei Group Corporation has spun out two programmes of its neurology pipeline into two newly created companies funded by venture fund Medicxi.