For decades, researchers have searched without success for a strategy to prevent malaria. Now, two teams of researchers present a solution that circumvents the problem of surface antigen hypervariability of Plasmodium. Their drug candidate blocks the pathogens’ release from blood cells, resulting in prevention of the life-threatening hot stages.
New Screening method for Antibiotic Discovery Pipeline
Latest NewsA new method that determines the mode of action underlying antimicrobial compounds could help overcome a major stumbling block in the ongoing effort to discover new antibiotics. Using it, reseachers from ETH Zurich zeroed in on compounds directed against tuberculosis.
App design for the cellular processor
BackgroundSince the earliest attempts at genetic engineering, scientists have sought to influence cell behaviour and development through the introduction of foreign genetic material. Synthetic biologists are now taking the idea to a whole new plane with app-like DNA-based software programs that turn cells into diagnostic sensors, therapeutic entities or tissue generators.
Cullinan Oncology partners with MAB Discovery
Latest NewsVirtual oncology company Cullinan Oncology, LLC has selecteed monoclonal antibody provider MAB Discovery GmbH (Neuried) to develop the first candidate of a target portfolio of 8-10 novel antibody therapeutics.
Sigurdur Olafsson appointed CEO of Hikma
AppointmentsHikma Pharmaceuticals today announces its Board of Directors has appointed Sigurdur (Siggi) Olafsson as Chief Executive Officer. Mr Olafsson will also join Hikma’s Board of Directors as an executive director, subject to election at the next annual general meeting in May 2018.
Locking malaria parasites into red blood cells
Latest NewsUK researchers headed by Michael Blackman have found out that a proteolytic cascade regulates release of merozoites of the human malaria parasite Plasmodium falciparum from host red blood cells. Inhibitition paves the way to block the parasite’s egress.
PharmaMar in licence deal with Seattle Genetics
Latest NewsSpanish specialist for sea-derived synthetic oncology drugs, PharmaMar SA, has inked a licence agreement with US antibody drug conjugate (ADC) company Seattle Genetics Inc. PharmaMar will provide fully-synthetic toxic payloads.
Plasmodium locked in
BackgroundFor decades, researchers have searched without success for a strategy to prevent malaria. Now, two teams of researchers present a solution that circumvents the problem of surface antigen hypervariability of Plasmodium. Their drug candidate blocks the pathogens’ release from blood cells, resulting in prevention of the life-threatening hot stages.
Roche to pay US$1.9bn for Flatiron Health
Latest NewsIn a strategic acquisition, Roche has completed its capabilities to use Big data to build new business cases in digital diagnostics solutions and personalised healthcare. The pharma major agreed to pay US$1.9bn to take over the US specialist for digital electronic medical records, Flatiron Health Inc.
Santhera licenses CF drug from Polyphor
Latest NewsSanthera Pharmaceuticals has licenced the inhaled neutrophil eleastase blocker POL6014 from Polyphor Ltd for CHF6.5m upfront and CHF121m in potential milestones.
AML: Sorafenib boosts graft-versus-leukemia activity
Latest NewsCo-administration of an allogenic blood stem cell transplant and sorafenib cured AML patients refractive to chemotherapy and stem cell transplants alone, oncologists report in Nature Medicine.