© GSK

GlaxoSmithKline plc announced belantamab mafodotin (GSK2857916) met the primary endpoint of overall response rate (ORR) in a pivotal Phase II trial in treatment-refractive multiple myeloma.

Steffen Brünle (right) and Jörg Standfuss at the apparatus they use to separate proteins from each other. For their study, the researchers modified insect cells to produce a human protein. To extract this from the cell, the cell was destroyed, and then the protein, whose structure the researchers have now elucidated, was separated with the help of this apparatus. © Paul Scherrer Institute/Markus Fischer

Researchers from Paul Scherrer Institute in Villingen, Switzerland, and Hoffmann La-Roche AG report in Cell they have solved the structure of a target relevant in metastasis.

Red blood cell. © pixabay

An antibody therapy that targets red blood cells (RBCs) unexpectedly showed anti-inflammatory effects and rapidly reversed rheumatoid arthritis and prevented lung injury in mouse models. 

Lefamulin blocks the peptidyl transferase site of the ribosome. © Nabriva Therapeutics plc
Nabriva Therapeutics plc has got the go from the FDA to market its pleuromutilin antibiotic Xenleta (lefamulin), a protein synthesis blocker with new mode-of-action to treat community-acquired bacterial pneumonia.
Araris Biotech CEO Philipp Spycher. © Paul Scherrer Institute/Mahir Dzambegovic

Zurich-based ADC maker Araris Biotech AG announced the closing of an oversubscribed seed financing round of CHF2.5m with Redalpine, Schroder Adveq and VI Partners contibuting.

Iteos Therapeutics SA, a privately-held biotechnology company developing novel cancer immunotherapies, last week announced the appointment of Matthew Call as its Chief Operating Officer. Matthew will also be responsible for business development.

Picture: Henrik Larsson/stock.adobe.com

Although it has only been shown to provide partial protection,  the first-ever malaria vaccine is in testing in Africa – and there are many more hopefuls in the pipeline. Will we soon eradicate one of the most deadly pathogens in human history?

The FDA has given the go-ahead to PharmaMar’s proposal to file for accelerated approval its New Drug Application (NDA) for lurbinectedin monotherapy for the treatment of second-line small-cell lung cancer.

Picture: Vetter

Manufacturers respond to stricter regulations with novel approaches.

Aerial image Karolinska Institutet Campus Flemingsberg, 2019. Photographer: barabild.se

Researchers at Karolinska Institutet have discovered a new sensory receptor organ that is able to detect painful mechanical damage, such as pricks and impacts.