eb_online_appointment_juuel.jpg

Bavarian Nordic A/S today announced the appointment of Henrik Juuel to the position of Executive Vice President and Chief Financial Officer. Mr. Juuel is currently the CFO of Orexo AB.

F-Star claims to be the first company that can create bispecifics that incorporate a binding site on the constant Fc region of the antibody. © EPvantage

Brain disease specialist Denali Therapeutics will buy all outstanding shares in British F-Star Gamma Ltd from F-Star instead licencing bispecific antibody candidates that can cross the blood-brain barrier (BBB) co-developed under an agreement dating back to 2016.

Picture © Cellectis

Nordic Nanovector ASA today announces that Rainer Boehm, MD was elected as a member of its Board of Directors at the company’s Annual General Meeting on 30 May 2018.

Roche announced that atezolimumab plus chemotherapy met its co-primary endpoints of overall survival (OS) and progression-free survival (PFS) as first-line treatment of stage IV nonsquamous non small cell lung cancer (NSCLC).

Picture © Nouscom

Nouscom, an immuno-oncology company developing off-the-shelf and personalized neoantigen-based genetic cancer vaccines, announced today the appointment of Adrian Woolfson M.D., Ph.D. as Chief Medical Officer (CMO).

Principle of CAR-T cell therapy. © Memorial Sloan Kettering Cancer Center

Interleukin 1 (IL-1) blockers may prevent serious adverse events triggered by CAR-T cell therapies, according to two independent studies.

CD38 antibodies attacking multiple myeloma cells. © Sumit Sharma/Pininterest

Following reports of an increase in mortality in a study that combined Genmab’s anti-CD38 daratumumab with a PD-L1 blocker, Genmab’s partner Janssen has stopped a study combining daratumumab with its PD1 blocker JNJ-63723283 in multiple myeloma.

Besides its RAS cancer vaccine, Targovax is testing an oncolytic virus + checkpoint inhibitor in cancer. © Targovax ASA

Targovax ASA’s cancer immunotherapy TG01 significantly prolonged 2-year overall survival of patients with resected pancreatic cancer versus standard therapy. Targovax’ shares were up 16% on Thursday evening.

The engineered SEMA3A protein markedly reduced the volume of metastatic tumors (red) in lymph nodes in mouse models of pancreatic cancer.
©  N. Gioelli et al., Science Translational Medicine (2018)

Italian oncologists have found a more effective tumour angiogenesis blocker which curbs metastasis and tumour growth. 

Molecule structure of Cara Therapeutics' pruritus candidate. © Cara Therapeutics

Vifor Fresenius Medical Care Renal Pharma has licenced ex-US/Japanese/Korean rights to commercialise CR845 (difelikefalin) from Cara Therapeutics for the treatment of chronic kidney disease-associated pruritus (CKD-aP).