Affimed's T cell engagers in contrast to most other bispecific antibodies are tetravalent. © Affimed NV

Genentech’s new partner Affimed NV has halted two blood cancer programmes with its tetravalent bispecific T cell engager AFM11 after a death and two cases of severe neurotoxicity occured in Phase I trails. 

Steven Docksey

Aglaris Ltd. yesterday announced the appointment of Steven Docksey to the role of CEO of the Anglo-Spanish cell therapy equipment manufacturer, effective immediately.

More than 15% of the 10.8 million people infected with M. tuberculosis die. (Picture: American Thoracic Society)

The Innovative Medicines Initiative 2 (IMI2) has launched a new Antimicrobial Resistance Accelerator Programme following on the heels of its outgoing NewDrugs4BadBugs programme.

Metabolic enzymes directly impact immunity. © Cell Metabolism, doi: 10.1016/j.cmet.2017.06.004

Oxford-based immunoncology player Sitryx Therapeutics Ltd. (Oxford, U.K.) has bagged $30m in a Series A financing round led by SV Health Investors and new investor Sofinnova Partners. Longwood Fund and GlaxoSmithKline plc participated in this financing.

Image: Exscientia

Exscientia, a company in Artificial Intelligence (AI)-driven drug discovery, has announced the appointment of Mr Georgy Egorov as Chief Financial Officer (CFO).

© Irchard Therapeutics

British gene therapy developer Orchard Therapeutics will go IPO on Nasdaq, according to SEC filings. The company plans to raise $172.5m as ADS in an IPO underwritten by J.P. Morgan, Goldman Sachs, Cowen and Wedbush PacGrow to balance its costs, which rose from US$13m to US$138m this year. Financial markets are expected to react positively.

Sphingotec CEO Andreas Bergmann will use the €20m from the financing round to roll out the IB-10 POC testing platforms with panels of innovative biomarker test to support therapy decision making and early diagnoses in medically underserved fields. © Sphingtotec GmbH

Diagnostics company sphingotec GmbH successfully closed a €20m growth equity financing round led by international specialist investors HBM Healthcare Investments, HBM BioCapital II LP (HBM) and Wellington Partners.

BRIDGES are aimed to brigde the valley of death in funding with mutual utility for all contributing partners. © Evotec AG
Evotec and Sanofi have launched a Public Private Partnership (PPP) aimed at partnering with academic groups in early stage drug discovery across multiple therapeutic areas. 
The engineered bispecific antibody targets p95HER2 (blue fragment), which is unique to malignant breast cancer cells (brown). The antibody can therefore guide T cells (blue cells) to cancer cells without attacking healthy breast epithelial cells (pink). © Vall d'Hebron Institute of Oncology (VHIO)

Researchers at at VHIO in Barcelona, Spain, and Roche in Schlieren have presented a bi-specific antibody that prevents the side effects of HER2-targeting compounds.

Medigene is developing the next generation of effective TCR cell therapies aimed at establishing better control over cancer at reasonable production cost.