Suggested mode of action of OSE-127: Blocking of an epitope overlapping the
IL-7 binding domain and the receptor heterodimerization region prevents activation of JAK/STAT signaling as well as PI3K and Erk
signaling, which blocks inflammation by neutralisation of IFN-gamma producing antigen-specific memory T cells © Nature Communicationsvolume 9, Article number: 4483 (2018)

Ose Immunotherapeutics has got the first milestone payment within its €272m deal with Servier inked in 2016.

The montage shows representative confocal images of siCTL HUVEC cells used in Kugeratski et al. F-actin, in white, is stained with phalloidin, Cortactin is in yellow and DAPI in blue.
© Amelie Juin

Analyses of the stroma cell proteome have revealed how intratumoral hypoxia triggers the formation of dysfunctional blood vessels that block drugs from entering the tumour and push metastasis.  

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Kiadis Pharma N.V., a clinical-stage biopharmaceutical company, on Monday announced the appointment of Robert Friesen, PhD as Chief Scientific Officer (CSO) effective February 1, 2019.

© Jennewein Biotechnologie
Jennewein Biotechnologie and Asia’s largest dairy company Yili Group have joined forces to develop an innovative infant formula tailored to the Chinese market.
Regulation through orexin A and B. @ www.cell.com/https://doi.org/10.1016/j.tem.2016.06.011

Sosei Group Corporation has spun out two programmes of its neurology pipeline into two newly created companies funded by venture fund Medicxi.

©123rf.com/ Nikolay Litov

EMA’s human medicines committee (CHMP) recommended six medicines for approval at its January 2019 meeting.

© apceth Biopharma Gmbh & Co KG

Hitachi Chemical Co. Ltd. is set to takeover cell and gene therapy CDMO apceth Biopharma GmbH to get a foothold in Europe, the second largest market for advanced therapies after the US.

© MPI-CBG

Dewpoint Therapeutics has attracted interested of investors with a completely new approach that might cure a huge array of  devasting diseases.

Making therapeutics inhalable is a bull market. ©123rf.com/decade3d

Marinomed has set the offer price for its IPO at Vienna Stock Exchange at the lower limit of €75 per new share. 

Picture: foxanon1987/shutterstock.com

Take the right dataset, add an ingenious algorithm or two – and voilá! Your billion-euro blockbuster molecule is ready! AI-driven drug development is exciting investor interest, while Big Pharma is also asking what forms of artifical intelligence can be slotted in at what stages in the process. AI-powered drug repurposing has seen some candidates enter clinical stage testing, but it’s still unclear whether the technology is already powerful enough for de novo molecule discovery.