French Servier boosts its cancer drug portfolio acquiring Shire plc’s oncology pipeline, which earned about US$260m last year, for US$2.4bn in cash. 

Federal Research Minister Anja Karliczek, © Nadine Rauß

Shortly before the Global Bioeconomy Summit (19.-20.4.2018) in Berlin will begin, Germany’s new Research Minister Anja Karliczek announced three major initiatives to strengthen the biologisation of the industry and the foundation of innovative biotechs.

Canopy Growth Corp. is growing its medical cannabis business in Europe with the acquisition of Czech market leader Annabis Medical sro.

© PIERRE GUERIN S.A.S.

Mid last year, the company Pierre Guerin has opened a new location in Germany, Hildesheim.

© Ian Wilson - Flickr, wikimedia commons

British drug major GlaxoSmithKline  (GSK) has passed its orphan autologous cell and gene therapy pipeline including its EU-approved ADA-SCID treatment Strimvelis to British/US Orchard Therapeutics. GSK acquired a 19,9% equity stake in Orchard and a board membership.

Oral once-daily WTX101 selectively reduced copper levels preventing neurological effects of currently available therapies. © Wilson Therapeutics AB

A public offer from orphan drug major Alexion Pharmaceuticals Inc. has been accepted by Wilson Therapeutics‘ Board of Directors. Alexion’s SEK232/share bid would total in an acqusition price of SEK6.564bn or €638.8m.

Location of neurons affected by spinal muscular atrophy in the spinal cord. © Angelito7, GNU licence

Swiss drug major Novartis has secured a potential stake in the multibillion dollar market of treatments for the orphan genetic muscle disease spinal muscular atrophy (SMA). The company acquired AveXis Inc, whose SMA gene therapy AVXS-101 is in Phase III testing.

Healthy and pathologically folded amyloid beta proteins absorb infrared light differently. In Alzheimer's patients, there is a frequency shift below the threshold level compared to healthy subjects. This is detected by the new blood test.
© K. Gerwert, A. Nabers / University Bochum

A newly developed blood test indicates Alzheimer’s disease on average eight years before the clinical diagnosis. 

Poor animal study design and reporting thwarts the ethical review of proposed human drug trials.
© nosheep/Pixabay

Human drug trials are compromised by poor reporting and potential bias of animal research. German researchers analysed more than 700 preclinical animal studies and investigator brochures provided by three medical centres. They call to establish documentation standards for IBs/preclinical dossiers.

Mode of action of OSE-172 ("Effi-Dem"). © Ose Immunotherapeutics

French  Ose Immunotherapeutics SA has licenced global commercialisation rights of its preclinical programme OSE-172 to Boehringer Ingelheim which hopes to complement its immunoncology portfolio with a tumour microenvironment modifier that reactivates effector T cell responses.