Colonic tissue of mice deficient in IL-10R (middle panel) was abundantly populated with type 3 innate lymphoid cells (red) and T helper 17 cells (green), both of which expressed elevated IL-22 levels compared to cells from control mice (left panel). © Bernshtein et al., Sci. Immunol. 4, eaau6571 (2019)

Researchers from Israel and the UK have identified how the cytokine IL-23 triggers inflammatory bowel syndrome (IBD), which affects 1.6 million patients annually in the US alone.

A laser-based technique detects circulating tumour cells in the veins of patients with melanoma.
[Credit: E.I. Galanzha et al., Science Translational Medicine (2019)]

German and US researchers have developed a diagnostic technique capable to detect one single circulating tumour cell in one litre of blood.

© ADC Therapeutics

Swiss antibody drug conjugate developer ADC Therapeutics SA raised $76m, bringing the total gross proceeds to $276 million in its Series E financing.

Genmab's research facility. © Genmab - Photo: Lucas van der Wee
Janssen Biotech Inc has inked a licence option contract with Genmab A/S on its next-generation anti CD38 antibody HexaBody®-CD38 and HexaBody platform technology.
© 123rf.com/Kateryna Kon

The Bill & Melinda Gates Foundation has granted Evotec SE $23.8m to identify the best drug combos to fight tuberculosis.

ILC2s moving around in the peribronchial (within small airway passages) and perivascular spaces (between blood vessels) of the mouse lungs. © Puttur et al., Sci. Immunol. 4, eaav7638 (2019)

The cells’ surrounding structures play an important role as cues from the immune system in guiding their motility and behaviour, researchers from the UK and the US report.

A cullin-RING ubiquitin ligase, silenced in the right hemisphere, inhibits the Lewy body-like pathology triggered by exogenous alpha-Synuclein fibrils.
© Natalia Prymaczok and Juan Gerez, Science Translat. Med. doi: 10.1126/scitranslmed.aau6722

An enzyme that clears out alpha-synuclein from neurons may counteract Parkinson’s Disease, report researchers from ETH Zürich and Novartis.

© 123rf.com/Kateryna Kon

Under a partnering ageement with CEPI, Themis Bioscience will receive $21m to push pivotal testing of MV-CHIK, its Chikungunya vaccine candidate.

© 123rf.com/kletr

A fungus that produces an insecticide can stop the spread of Anopheles mosquito, which causes malaria.

© Abacus Medicine

European pharmaceutical parallel trade company Abacus Medicine A/S has postponed its planned Initial Public Offering (IPO), due to "unfavourable market environment".