Steffen Brünle (right) and Jörg Standfuss at the apparatus they use to separate proteins from each other. For their study, the researchers modified insect cells to produce a human protein. To extract this from the cell, the cell was destroyed, and then the protein, whose structure the researchers have now elucidated, was separated with the help of this apparatus. © Paul Scherrer Institute/Markus Fischer

Researchers from Paul Scherrer Institute in Villingen, Switzerland, and Hoffmann La-Roche AG report in Cell they have solved the structure of a target relevant in metastasis.

Red blood cell. © pixabay

An antibody therapy that targets red blood cells (RBCs) unexpectedly showed anti-inflammatory effects and rapidly reversed rheumatoid arthritis and prevented lung injury in mouse models. 

Lefamulin blocks the peptidyl transferase site of the ribosome. © Nabriva Therapeutics plc
Nabriva Therapeutics plc has got the go from the FDA to market its pleuromutilin antibiotic Xenleta (lefamulin), a protein synthesis blocker with new mode-of-action to treat community-acquired bacterial pneumonia.
Araris Biotech CEO Philipp Spycher. © Paul Scherrer Institute/Mahir Dzambegovic

Zurich-based ADC maker Araris Biotech AG announced the closing of an oversubscribed seed financing round of CHF2.5m with Redalpine, Schroder Adveq and VI Partners contibuting.

The FDA has given the go-ahead to PharmaMar’s proposal to file for accelerated approval its New Drug Application (NDA) for lurbinectedin monotherapy for the treatment of second-line small-cell lung cancer.

Aerial image Karolinska Institutet Campus Flemingsberg, 2019. Photographer: barabild.se

Researchers at Karolinska Institutet have discovered a new sensory receptor organ that is able to detect painful mechanical damage, such as pricks and impacts.

Mitosis. ©  By Mysid - Vectorized in CorelDraw by Mysid / https://commons.wikimedia.org/w/index.php?curid=1414818

British researchers have found out what’s going wrong with chromosome segregation in some cancers. 

© Pharming
Pharming NV has paid €17.9m upfront to Novartis AG for an exclusive license to CDZ173, a late stage drug for the treatment of APDS
Group of mesenchymal (green) stem cells migrating in a tooth to further regenerate tissues.
© Media and Communications | University of Plymouth

Researchers have discovered that crosstalk of a newly discovered stem cell population with quiescent stem cells may help repair teeth in the future.

iPSCs derived from somatic cells through a novel reprogramming method. © UCLA Broad Stem Cell Research Center/Plath Lab

Bayer has widened its pipeline in neurology, cardiology, and immunology by acquiring induced pluripotent stem cell specialist BlueRock Therapeutics.