Postulated MoA for adrecizumab, Adrenomed's white hope to treat septic shock and acute congestive heart failure. The antibody, which can't pass the endothelium, leads to redistribution of adrenomedullin (ADM) from the interstitium  where it is produced  to the blood vessel lumen without affecting ADM activity. Relocation of adrenomedullin to the lumen prevents its vasodilatory effects in tissue but promotes its endothelium-stabilising effect. Phase II trials will be designed to show whether the first-in-class antibody diminishes congestion without affecting blood pressure. @ Adrenomed AG
German Adrenomed AG has decided to start clinical Phase II tests of the very first personalised treatment for the six million patients with acute congestive heart failure. Large trials suggest that the company can stratify patients resistant to diuretics standard therapy by a proprietary companion diagnostics blood test. Adrenomed will assess whether its first-in-class antibody adrecizumab can reverse the congestion that that manifests as pulmonary edema.

The French biotech said that its lead therapeutic candidate demonstrated the first reduction in HIV reservoirs ever observed in chronically infected HIV patients. Following the news, the company’s share price more than doubled.