Scaling precision fermentation
To address the demands of a growing population and enhance food and nutrition security, a transition from traditional chemical-derived production is essential. Biomanufacturing, known for its efficient use of natural resources, offers an ideal solution. Acies Bio recently added fermentation capacity and more versatile equipment for downstream processing and formulation.
The global demand for new fermentation technologies is rapidly growing, yet the capacity to meet this demand lags behind. Acies Bio, a leading European microbial biotechnology company, is addressing this issue with a pilot facility boasting a fermentation volume exceeding 35 m3. Equipped to handle a broad range of fermentation volumes, from 1L to 10,000L, Acies Bio is well-prepared. The team of skilled scientists and bioprocess engineers possesses extensive expertise with diverse microbial species, including bacteria, yeast, filamentous fungi, and more exotic microbes.
Scaling biomanufacturing
Fast scale-up of fermentation and isolation processes is crucial for introducing new products to the market. Acies Bio combines state-of-the-art fermentation capabilities with a diverse range of downstream processing (DSP) equipment, enabling the seamless execution of even the most complex operations in one location. This integrated approach not only saves time but also optimises resources. In many cases, downstream processing plays a pivotal role in ensuring the effective performance of new technologies. Acies Bio’s expertise extends to biomass separation techniques such as centrifugation and filtration, cell disruption, solvent extraction, precipitation, and various chromatographic steps for final purification. Additionally, the company specialises in diverse drying approaches for live microorganisms, including vacuum drying, spray drying, fluid-bed drying, freeze drying, and encapsulation. This extensive knowledge, coupled with cutting-edge technology and strong in-house analytical support, positions Acies Bio as an ideal research and development (R&D) and small-scale Contract Manufacturing Organisation (CMO) partner, ensuring high productivity for various microbial products and maintaining favourable goods costs (COGS) throughout their lifecycle.
Acies Bio recently formed a strategic partnership, enhancing its CMO capabilities with an additional fermentation capacity of up to 200 m3 (4 x 50 m3) within the EU-based One-Stop-Shop offering. This expansion facilitates a streamlined development process for microbial technologies, from concept design to biomanufacturing, effectively addressing scalability challenges in a time- and cost-efficient manner.
The R&D team, fortified by this strategic partnership, focuses on developing a robust strain, bioprocess, and downstream scheme, ensuring efficiency and reliability. This approach allows a seamles scale-up to meet demand without protracted technology transfer steps or unexpected legal obstacles. With the combined R&D and production expertise, Acies Bio is dedicated to supporting partners in enhancing sustainability and expanding their innovative microbial-based portfolio. Choose Acies Bio for a reliable and efficient path to innovation in sustainable microbial-based products.
Contact us:
ACIES BIO D.O.O.
TEHNOLOKI PARK 21
1000 LJUBLJANA
SLOVENIJA
+386 59 075 995
E-Mail: info@aciesbio.com
Cradle.bio
Roche, Herzog&De Meuron
PharmaMar SA