The engineered SEMA3A protein markedly reduced the volume of metastatic tumors (red) in lymph nodes in mouse models of pancreatic cancer.
©  N. Gioelli et al., Science Translational Medicine (2018)

Italian oncologists have found a more effective tumour angiogenesis blocker which curbs metastasis and tumour growth. 

Molecule structure of Cara Therapeutics' pruritus candidate. © Cara Therapeutics

Vifor Fresenius Medical Care Renal Pharma has licenced ex-US/Japanese/Korean rights to commercialise CR845 (difelikefalin) from Cara Therapeutics for the treatment of chronic kidney disease-associated pruritus (CKD-aP).

Celgene headquarters. © Celgene Corp.

Evotec AG and Celgene Corporation have entered into a strategic drug discovery and development partnership to identify new therapeutics in oncology.

Finnish Arctic Biomaterials won the "Innovation Award  Bio-based Material of the Year. © BIOCOM/Nova Institute

Bioeconomy industry experts  gave a mixed outlook for biomaterials in mid-May in Cologne where about 200 stakeholder joined  the 11th International Conference on Bio-based Materials.

Human colon cancer cells injected into mice form tumors (left) consisting of both MAPK-active cells (green) and NOTCH-active cells (red). Treatment with the MAPK inhibitor selumetinib results in tumors consisting of NOTCH-active cells only (center), but after treatment is stopped, the NOTCH-active cells give rise to new MAPK-active cells, restoring the tumors' original composition (right). ©Schmidt et al., 2018, JEM

Researchers at LMU Munich have unraveled a new strategy of colon cancers to evade targeted therapies. 

Kite's facility in Hoofddorp, Netherlands. © Kite

CAR-T cell therapy specialist Kite Pharma, now part of Gilead Sciences, has expanded its cell therapy manufacturing footprint in Europe. A 117,000 square-foot facility in Hoofddorp, the Netherlands, will be operational by 2020. 

Cell clone selection at MediGene. © MediGene AG

CAR-T cell developer bluebird bio Inc. has extended its potential US$1bn deal with cancer neoantigen TCR specialist MediGene by two new targets adding US$500m potential revenues to the licence agreement.

Mode of action of benralizumab. © AstraZeneca

British drug maker AstraZeneca’s IL-5Ralpha blocker benralizumab did not reduce exacerbations significantly compared to placebo in patients with moderate to severe chronic obstructive pulmonary disease (COPD).

Credit: Kun Liang, Simone Carmone, Davide Brambilla, Jean-Christophe Leroux

A research team headed by Jean-Christophe Leroux from ETH Zurüch has created the first-ever 3-D printed mouth guard that could deliver drugs to the wearer and is highly customizable, in terms of drug release and design. 

Following weeks of negotiations and four rejected bids, British neurology and orphan drug giant Shire has agreed to Takeda’s latest take-over offer of £46bn (€52,38bn).