F-Star claims to be the first company that can create bispecifics that incorporate a binding site on the constant Fc region of the antibody. © EPvantage

Brain disease specialist Denali Therapeutics will buy all outstanding shares in British F-Star Gamma Ltd from F-Star instead licencing bispecific antibody candidates that can cross the blood-brain barrier (BBB) co-developed under an agreement dating back to 2016.

Roche announced that atezolimumab plus chemotherapy met its co-primary endpoints of overall survival (OS) and progression-free survival (PFS) as first-line treatment of stage IV nonsquamous non small cell lung cancer (NSCLC).

Principle of CAR-T cell therapy. © Memorial Sloan Kettering Cancer Center

Interleukin 1 (IL-1) blockers may prevent serious adverse events triggered by CAR-T cell therapies, according to two independent studies.

CD38 antibodies attacking multiple myeloma cells. © Sumit Sharma/Pininterest

Following reports of an increase in mortality in a study that combined Genmab’s anti-CD38 daratumumab with a PD-L1 blocker, Genmab’s partner Janssen has stopped a study combining daratumumab with its PD1 blocker JNJ-63723283 in multiple myeloma.

Besides its RAS cancer vaccine, Targovax is testing an oncolytic virus + checkpoint inhibitor in cancer. © Targovax ASA

Targovax ASA’s cancer immunotherapy TG01 significantly prolonged 2-year overall survival of patients with resected pancreatic cancer versus standard therapy. Targovax’ shares were up 16% on Thursday evening.

The engineered SEMA3A protein markedly reduced the volume of metastatic tumors (red) in lymph nodes in mouse models of pancreatic cancer.
©  N. Gioelli et al., Science Translational Medicine (2018)

Italian oncologists have found a more effective tumour angiogenesis blocker which curbs metastasis and tumour growth. 

Molecule structure of Cara Therapeutics' pruritus candidate. © Cara Therapeutics

Vifor Fresenius Medical Care Renal Pharma has licenced ex-US/Japanese/Korean rights to commercialise CR845 (difelikefalin) from Cara Therapeutics for the treatment of chronic kidney disease-associated pruritus (CKD-aP).

Celgene headquarters. © Celgene Corp.

Evotec AG and Celgene Corporation have entered into a strategic drug discovery and development partnership to identify new therapeutics in oncology.

Finnish Arctic Biomaterials won the "Innovation Award  Bio-based Material of the Year. © BIOCOM/Nova Institute

Bioeconomy industry experts  gave a mixed outlook for biomaterials in mid-May in Cologne where about 200 stakeholder joined  the 11th International Conference on Bio-based Materials.

Human colon cancer cells injected into mice form tumors (left) consisting of both MAPK-active cells (green) and NOTCH-active cells (red). Treatment with the MAPK inhibitor selumetinib results in tumors consisting of NOTCH-active cells only (center), but after treatment is stopped, the NOTCH-active cells give rise to new MAPK-active cells, restoring the tumors' original composition (right). ©Schmidt et al., 2018, JEM

Researchers at LMU Munich have unraveled a new strategy of colon cancers to evade targeted therapies.