Formation of neuronal spines in neurons from wild type mice (left) and mice with mutations in the KCC2 transporter. © M. Watanabe et al., Science Signaling (2019)

A molecular transporter is critical for the proper maturation of neurons underlying neurodevelopmental disorders.

© pixabay/Gerd Altmann

AI-driven drug repurposing company Healx Ltd (Cambridge, UK) raises US$56m in a Series B financing and launches global accelerator programme for orphan diseases.
 

Besides DONIMI, 4SC AG is conducting clinical testing of domatinostat in a range of indications. © 4SC AG

The Netherlands Cancer Institute (NKI) has joined 4SC AG as a partner in conducting a multicentre study of dominatostat/checkpoint blocker combos in treatment-naive melanoma patients.

© Mogrifiy

British start-up company Mogrify Ltd (Cambridge, UK) has added US$16m from a Series A round to its US$3.7m seed financing in February 2019. Existing investor Ahren Innovation Capital led the round, with Parkwalk, 24Haymarket, and the University of Bristol Enterprise Fund III participating.

Bright field image of patient-derived organoids in culture. © S.N. Ooft and M. Mertz

A new test based on tumour organoids can predict how patients with advanced colorectal cancer respond to chemotherapy treatment.

Affimer. © Avacta Group plc

ADC Therapeutics SA has entered a R&D pact with Affimer developer Avacta Group plc aimed at creating and licencing Affimer drug conjugates.

© Pixabay/Clker-Free-Vector-Images

Licencing bluebird bio’s Inc know-how and technology in one-time gene therapies, Novo Nordisk A/S tries to get a foothold in the emerging haemophilia A gene therapy market.

Evotec SE has expanded its drug discovery customer base with US women’s health specialist Celmatix Inc.

QIAGEN and Illumina join forces in the next-gen sequencing-based IVD testing and companion diagnostics market announcing a 15-year collaboration. 

Three cryo-electron microscopic views of the protein complex ClpX-ClpP. © C. Gatsogiannis / MPI of Molecular Physiology

German researchers have determined the mechanism of a ADEPs, a novel class of antibiotics, allowing for pharmacological optimisation.