Drug Developers dealing with PD1-PDL1 checkpoint inhibitors must consider new safety problems associated with the hyped cancer meds. 

EIB

The European Investment Bank (EIB) has issued its first Sustainability Awareness Bond worth €500m to support investments into water projects – health and nutrition to follow.

300 AMR experts met at ESCMID-ASM conference in Lisbon. © BIOCOM AG

Around 300 international AMR experts met at ESCMID-ASM drug development conference in Lisbon to discuss the latest progress in the field. 

Adaptimmune's workflow to make SPEAR cells with optimised TCRs. © Adaptimmune Therapeutics Ltd

Oxford-based Adaptimmune Therapeutics plc has raised US$100m in a registered direct offering of American Depositary Shares (ADS).

© Celgene

The NHS England announces it will reimburse Novartis’ CAR-T cell therapy Kymriah as treatment for children with B cell acute lymphoblastic leukemia (ALL) that are refractory, in relapse post-transplant or in second or later relapse. 

Functionalised exosome with drug payload. © Evox Therapeutics Ltd

Exosome drug delivery specialist Evox Therapeutics Ltd has closed a €37.1m (£35.5m) Series B financing round led by Redmile Group and significant contributions from GV (Google Ventures) and Cowen Healthcare Investments.

Approved (bold) and experimental therapies for aTTP. © NEJM doi: 10.1056/NEJMe1515876

The EU approved Sanofi’s Cablivi (caplacizumab) as the first antibody therapeutic to treat acquired thrombotic thrombocytopenic purpura (aTTP) on Friday. 

Ultraviolet radiation causes accumulation of collagen in the skin of mice deficient in the Cockayne syndrome group B (CSB) protein. © M. Majora et al., Science Translational Medicine (2018)

An FDA-approved cancer drug stops light sensitivity of the skin in Cockayne syndrome (CS), an ultra-rare hereditary disease characterised by premature aging, German researchers report.

German Research Minister Anja Karliczek and Economics Minister Peter Altmaier make a joint statement on the founding of the Agency for Jump Innovations following the meeting of the Federal Cabinet. © BMBF / Hans-Joachim Rickel

Germany’s government announced that it will create an agency for breakthrough ("jump") innovation to foster technology transfer of risky research projects with high market potential into products.

How OAB symptoms emerge. © atlanticurologyclinics.com
Urovant Sciences has licensed the global commercialisation rights for Ion Channel Innovations‘ gene therapy hMaxi-K for patients with overactive bladder (OAB) symptoms who have failed oral pharmacologic therapy.