Metabolic enzymes directly impact immunity. © Cell Metabolism, doi: 10.1016/j.cmet.2017.06.004

Oxford-based immunoncology player Sitryx Therapeutics Ltd. (Oxford, U.K.) has bagged $30m in a Series A financing round led by SV Health Investors and new investor Sofinnova Partners. Longwood Fund and GlaxoSmithKline plc participated in this financing.

© Irchard Therapeutics

British gene therapy developer Orchard Therapeutics will go IPO on Nasdaq, according to SEC filings. The company plans to raise $172.5m as ADS in an IPO underwritten by J.P. Morgan, Goldman Sachs, Cowen and Wedbush PacGrow to balance its costs, which rose from US$13m to US$138m this year. Financial markets are expected to react positively.

Sphingotec CEO Andreas Bergmann will use the €20m from the financing round to roll out the IB-10 POC testing platforms with panels of innovative biomarker test to support therapy decision making and early diagnoses in medically underserved fields. © Sphingtotec GmbH

Diagnostics company sphingotec GmbH successfully closed a €20m growth equity financing round led by international specialist investors HBM Healthcare Investments, HBM BioCapital II LP (HBM) and Wellington Partners.

BRIDGES are aimed to brigde the valley of death in funding with mutual utility for all contributing partners. © Evotec AG
Evotec and Sanofi have launched a Public Private Partnership (PPP) aimed at partnering with academic groups in early stage drug discovery across multiple therapeutic areas. 
The engineered bispecific antibody targets p95HER2 (blue fragment), which is unique to malignant breast cancer cells (brown). The antibody can therefore guide T cells (blue cells) to cancer cells without attacking healthy breast epithelial cells (pink). © Vall d'Hebron Institute of Oncology (VHIO)

Researchers at at VHIO in Barcelona, Spain, and Roche in Schlieren have presented a bi-specific antibody that prevents the side effects of HER2-targeting compounds.

Life Sciences venture capitalist Forbion has closed its  new flagship fund, Forbion IV, at €360m, €90m above its original target of €250m.

© ASEBIO

Matured, diversified and willing to expand – this is how the Spanish biotech sector presented itself during BIOSPAIN 2018 in Seville. Andalusia has launched the first bioeconomy policy strategy in Spain. 

© Minory Therapeutics SL

Barcelona-based Minoryx Therapeutics announced during BIOSPAIN 2018 it has raised another €21.3m in a Series B financing bringing its assets to a total of €50M. 

A team of researchers from the US and the UK have found that CD4-positive T cells harboring the PD-1 immune checkpoint protein can promote excessive connective tissue formation in lung cells. 

Monoclonal antibodies blocking both PD1 and PDL1 in cancer microenvironment. Currently, four checkpoint inhibitors are approved to treat lung cancer: Merck & Co's pembrolizumab, BMS' nivolumab, AstraZeneca's durvalumab, and Roche's atezolizumab. © Pharmaceutical.com

Cancer immunotherapy has been heralded as paradigm change in cancer treatment. Now, Roche’s US arm Genentech announced that the company’s anti-PD-L1 checkpoint inhibitor atezolizumab (Tecentriq) improved survival by only two months as first-line treatment for patients with the rare lung cancer SCLC.