© 123rf.com/Kateryna Kon

The Bill & Melinda Gates Foundation has granted Evotec SE $23.8m to identify the best drug combos to fight tuberculosis.

ILC2s moving around in the peribronchial (within small airway passages) and perivascular spaces (between blood vessels) of the mouse lungs. © Puttur et al., Sci. Immunol. 4, eaav7638 (2019)

The cells’ surrounding structures play an important role as cues from the immune system in guiding their motility and behaviour, researchers from the UK and the US report.

A cullin-RING ubiquitin ligase, silenced in the right hemisphere, inhibits the Lewy body-like pathology triggered by exogenous alpha-Synuclein fibrils.
© Natalia Prymaczok and Juan Gerez, Science Translat. Med. doi: 10.1126/scitranslmed.aau6722

An enzyme that clears out alpha-synuclein from neurons may counteract Parkinson’s Disease, report researchers from ETH Zürich and Novartis.

© 123rf.com/Kateryna Kon

Under a partnering ageement with CEPI, Themis Bioscience will receive $21m to push pivotal testing of MV-CHIK, its Chikungunya vaccine candidate.

© 123rf.com/kletr

A fungus that produces an insecticide can stop the spread of Anopheles mosquito, which causes malaria.

© Abacus Medicine

European pharmaceutical parallel trade company Abacus Medicine A/S has postponed its planned Initial Public Offering (IPO), due to "unfavourable market environment". 

The study authors include Charles de Bock (left), Jan Cools, Roger Habets, and Bart De Strooper.
© VIB

A Belgian-British-Australian research team has created a safer version of a therapy that combats the aggressive form of a blood cancer called acute lymphoblastic leukemia (ALL) while avoiding toxicity.

Ratio of nanomedicine accumulated or cleared in the liver (red) or delivered to the target site (green). © Curadigm

Cancer-focussed Nanobiotix SA has spun out Curadigm, which offers a platform to improve the bioavailability of nanomedicines by reducing liver and spleen toxicity and accumulation.

123rf.com/Sebastian Kaulitzki

It was a good day for Novartis: A second drug with huge selling potential has been approved for the US market. The FDA gave the go ahead for breast cancer drug Piqray (alpelisib), the first and only treatment developed specifically for patients with a PIK3CA mutation in HR+/HER2-advanced breast cancer.

© 123rf.com/ ktsdesign

The FDA has approved Novartis-subsidiary AveXis Inc’s spinal muscular atrophy (SMA) gene therapy Zolgensma (onasemnogene abeparvovec-xioi). The company wants to set the price tag at $2,125m per dose.