Sphingotec headquarters, © Sphingotec GmbH

Data from 1,200 heart failure patients demonstrate that high discharge levels of the biomarker bio-ADM® (bioactive Adrenomedullin) indicate residual congestion in heart failure patients.

© VIB

The new company, named Augustine Therapeutics, is a Vlaams Instituut voor Biotechnologie (VIB) and Katholieke Universiteit (KU) Leuven spin-off. Funded with €4.2m from mainly local investors, Augustine’s first priority is finding new therapeutics for patients suffering from Charcot-Marie-Tooth disease, a hereditary motor and sensory neuropathy of the peripheral nervous system.

Transgene's CEO Philiippe Archinard. © Transgene SA

French Transgene SA said it has terminated its lead programme TG4010 in combination with chemotherapy and checkpoint inhibition. 

Inflamed hair follicles during EGFR inhibition.© Jo?rg Klufa and Thomas Bauer, Medical University Vienna

New research demonstrates that disruption of EGF receptor signalling allows commensal bacteria to invade hairs and cause skin lesions.

In clinical trials, BO-112, the first cancer immunotherapeutic developed in Spain, shrinked tumour volume by 15% in 56% of patients. © BIOncoTech Therapeutics

Madrid-based RNA specialist Bioncotech Therapeutics has entered into a Phase II clinical trial collaboration with a MSD subsidiary.

© University Hospital Bern/J. Gralla

Swiss surgeons have significantly improved mechanical removal of blood clots in stroke patients by intra-arterial administration of the thromolytic urokinase.

Adverse effects triggered by unmodified IL-2. © Synthorx Inc

Sanofi will acquire Synthorx Inc to expand its  immuno-oncology pipeline with THOR-707, an optimised IL-2 candidate.

Meatable managers in the lab. @ Meatable

Meatable NV, a specialist for cultivated meat, has raised an additional US$10m in seed funding, bringing the company’s total funding to US$13m.

© Pixabay

Médecins Sans Frontières (MSF) called on the GAVI Vaccine Alliance not to pay huge subsidies to Big Pharma companies for pneumococcal vaccine

ICT01 is an activating mAb targeting the extracellular domain of BTN3A that leads to activation and trafficking of ?9?2 T cells out of the circulation.  ICT01 has been shown to promote an anti-tumor immune response against a range of cancers in in vitro and in mouse tumor models. In primates, ICT01 rapidly occupies its target and specifically activates ?9?2 T cells with a good safety profile that supports clinical testing. © ImCheck Therapeutics SAS

T cell agonist specialist ImCheck Therapeutics will use €48m (US$53m) from a Series B financing to push clincial pipeline of antibodies activating gamma-delta T-cells.