Antimicrobial resistance (AMR) is a global threat, particularly given the modest activity in the pipeline of new antimicrobials in development, and emerging resistance to existing antibiotics. In 2016, Lord Jim O’Neill published a globally-focused review on AMR, which highlighted the lack of incentives for new antimicrobial development and encouraged a worldwide system of push’ and pull’ incentives to stimulate new drug development.
Pfizer buys stake in liver gene therapy player Vivet
Latest NewsPfizer Inc has paid €45m upfront to French gene therapy specalist Vivet Therapeutics in a licence option deal for Vivet’s preclinical Wilson disease candidate VTX-801.
Sotio on track for 2nd Phase III trial
Latest NewsAfter positive preliminary results of Sotio’s SOV02 trial in ovarian cancer had been presented last year, the final analysis confirmed the survival benefits. The Czech biotech company now plans to initiate a global Phase III study with its autologous cell-based immunotherapy also in this indication.
AMR Conference in Berlin: Call for better incentives
Latest NewsMore than 330 experts joined the 2-day AMR Conference 2019 in Berlin. They called for rapid capital investments and economic incentives in the fight against antimicrobial resistance (AMR).
Biomarker can exclude acute kidney injury
Latest NewsResearchers target neuroblastoma with ALK-ADC
Latest NewsResearchers at Celldex Therapeutics, Inc and Nerviano Medical Science Srl report elimination of the most common childhood cancer by an ADC in xenografted mice expressing either wild-type or mutated ALK.
AMR: Germany set to invest €39m into CARB-X
Latest NewsGlobal antibacterial innovation network CARB-X announced during an AMR business conference in Berlin that Germany has joined the CARB-X partnership.
Financing AMR innovation discussed globally
BackgroundFinancing of AMR innovation is shifting gears in early 2019. US AMR accelerator CARB-X has expanded its global reach, the Novo REPAIR impact fund reflects on their first and upcoming investments, and the British Government is underway to take first steps for a pull mechanism this year. During the Novel Antimicrobials and AMR Diagnostics conference in mid-March in Berlin, 300 international AMR experts will discuss the status quo.
Encourage development of new antimicrobials
OpinionAntimicrobial resistance (AMR) is a global threat, particularly given the modest activity in the pipeline of new antimicrobials in development, and emerging resistance to existing antibiotics. In 2016, Lord Jim O’Neill published a globally-focused review on AMR, which highlighted the lack of incentives for new antimicrobial development and encouraged a worldwide system of push’ and pull’ incentives to stimulate new drug development.
“We need to grow”
BackgroundWhy the US AMR accelerator aims to expand its reach in Europe to support antibacterial R&D, and why it is important to bundle global resources, explains Kevin Outterson, Executive Director of CARB-X.
AstraZeneca partners with Seres Therapeutics
Latest NewsUnder a three-year agreement, British pharma giant AstraZeneca plc pays €20m and R&D costs to Seres Therapeutics Inc, which will identify patterns in the microbiome predicting therapy response to cancer immune therapies.