Human colon cancer cells injected into mice form tumors (left) consisting of both MAPK-active cells (green) and NOTCH-active cells (red). Treatment with the MAPK inhibitor selumetinib results in tumors consisting of NOTCH-active cells only (center), but after treatment is stopped, the NOTCH-active cells give rise to new MAPK-active cells, restoring the tumors' original composition (right). ©Schmidt et al., 2018, JEM

Researchers at LMU Munich have unraveled a new strategy of colon cancers to evade targeted therapies. 

Kite's facility in Hoofddorp, Netherlands. © Kite

CAR-T cell therapy specialist Kite Pharma, now part of Gilead Sciences, has expanded its cell therapy manufacturing footprint in Europe. A 117,000 square-foot facility in Hoofddorp, the Netherlands, will be operational by 2020. 

Cell clone selection at MediGene. © MediGene AG

CAR-T cell developer bluebird bio Inc. has extended its potential US$1bn deal with cancer neoantigen TCR specialist MediGene by two new targets adding US$500m potential revenues to the licence agreement.

Mode of action of benralizumab. © AstraZeneca

British drug maker AstraZeneca’s IL-5Ralpha blocker benralizumab did not reduce exacerbations significantly compared to placebo in patients with moderate to severe chronic obstructive pulmonary disease (COPD).

Credit: Kun Liang, Simone Carmone, Davide Brambilla, Jean-Christophe Leroux

A research team headed by Jean-Christophe Leroux from ETH Zurüch has created the first-ever 3-D printed mouth guard that could deliver drugs to the wearer and is highly customizable, in terms of drug release and design. 

Terry Pizzie

Horizon Discovery Group plc has announced the appointment of Terry Pizzie as Chief Executive Officer and Board Director with immediate effect.

Americans and Europeans love fast food, even though doctors are now more certain than ever that the highly processed meals that go hand-in-hand with a hectic Western lifestyle are not a smart health choice. The latest findings suggest that fa(s)t food imprint key genes in the innate immune system, possibly causing the permanent immunological hypersensivity that is at the root of diabetes, atherosclerosis and other common diseases of civilisation.

Following weeks of negotiations and four rejected bids, British neurology and orphan drug giant Shire has agreed to Takeda’s latest take-over offer of £46bn (€52,38bn).

Liam Condon, Picture © Bayer.

Bayer today announced the selection of the new Executive Leadership Team for the Crop Science division, which will go into effect as of the closing of Bayer’s proposed acquisition of Monsanto. The closing is still subject to pending regulatory approval.

© BIOCOM AG

Vas Narasimhan, the newly appointed CEO of Swiss pharma giant Novartis, introduced himself to the Swiss biotech industry with a stimulant talk at the Swiss Biotech Day. Apart from that participants of the annual gathering were in high spirits as the Swiss biotech sector continues to grow steadily.