G7 environment ministers in Berlin. © BMUV, Sascha Hilgers

G7 Climate, Energy and Environment Ministers have announced a wide range of actions to tackle the triple global crisis of climate change, biodiversity loss and pollution".
 

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An anti-idiotypic anti­body (anti-ID Ab) can recognise and bind to the idiotypic center of another antibody. Anti-idiotype antibodies are widely used in therapeutic drug development, such as immunogenicity assessments, pharmacokinetic/pharmacodynamics (PK/PD) studies, and vaccine development.

HER3 (ErbB3) was found to be kinase impaired, having only 1/1000 the autophosphorylation activity of EGFR and no ability to phosphorylate other proteins. Therefore, ErbB3 acts as an allosteric activator that heterodimerize with any of the other three ErbB family members. © Sino Biological

Ellipses Pharma and SunRock Biopharma enter into a licensing agreement for a first-in-class bifunctional HER3:TRAIL fusion protein set to eliminate solid tumours.

Picture: Foreign, Commonwealth & Development Office, UK

COVID-19 is the acute pandemic, while antimicrobial resistance (AMR) is a silent, pandemic. New data makes the AMR pandemic visible, with the first global study of AMR estimating that 1.27 million people die from AMR every year, making AMR the 12th-leading cause of death globally.

A pancreatic islet from a mouse in a typical position, close to a blood vessel; insulin in red, nuclei in blue. © Jakob Suckale

Hamburg-based CRO Evotec SE has inked a drug development partnership with Spanish Almirall SA in dematology.

© Avantium

Avantium NV will get a €3m EU funding for a feasibility study of the electrochemical conversion of CO2 to consumer products.

Ningbo R&D site building. © Enzymaster

Biocatalysis expert Enzymaster (Germany, China, Singapore) has cashed in $45m to expand its production capacity of engineered biosynthetic enzymes.

© JKI

The EU Commission has launched its final consultation on the deregulation of new breeding techniques in agriculture.

© Evotec SR

Hamburg-headquartered Evotec SE has extended and expanded its three-year-old partnership with Bristol Myers Squibb in targeted protein degradation ("molecular glue degraders") for an additional eight years. 

The small molecule degraders link an E3 ubiquitin ligase with the molecular target, mostly in cancer and autoimmunity indications. The interaction results in ubiquitination and subsequent degradation of the recruited protein and is hoped to provide a ong-lasting therapeutic effect.
Bristol Myers Squibb brings in a huge library of E3 ligase modulators. Under the terms of the agreement, both parties will leverage all of Evotec’s appropriate platforms as well as AI/ML-based drug discovery.
Under the new agreement, Evotec cashes in an upfront payment of $200m and is eglible to obtain up to $5bn in milestone payments and tiered royalties on product sales. 
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The optically pumped semiconductor laser (OPSL) is an ideal light source for structured illumination microscopy (SIM), a laser fluorescence technique that can deliver unique information in drug discovery.