Affinity Maturation Service

Sino Biological and Ainnocence have joined forces to establish an AI-enabled platform for antibody affinity maturation.

Powered by a self-evolving artificial intelligence engine, Ainnocence’s SentinusAI is revolutionizing affinity maturation processes. SentinusAI can effectively rank up to 10^10 antibody sequences based on their predicted affinity towards one or more antigens within a few days. Combined with the high-throughput recombinant antibody development program at Sino Biological, top candidates can be expressed recombinantly at a lower cost and shorter lead time to generate affinity data with a high hit rate of 15%.

SentinusAI is a powerful and self-evolving protein design engine created by Ainnocence. Its database contains up to 100 million human antibody sequences as well as an extensive collection of human/animal viral antigen information, resulting in high-confidence prediction of binding affinity. Antibody affinity maturation is a popular module of SentinusAI. Its close-loop nature guarantees that the model creates better antibodies by learning from each cycle of the experimental results. It has since delivered affinity-matured antibody sequences with an average hit rate of 15% and successfully increased affinity by three orders of magnitude.