Nano and Micro Formulation conference
To deliver sufficient quantities of a drug to their pharmacological target, scientists already use nanocarriers, which release their cargo at the target site.
How to manufacture, characterise, and control the drug-release mechanism for the next generation of nanomedicines is the focus of investigation at the Research Center for Translational Medicine and Pharmacology (TMP) in Frankfurt, a collaboration between the Fraunhofer-Institute for Molecular Biology and Applied Ecology, and Goethe University. Researchers also hope to identify critical quality attributes and establish predictive models for in vivo applications.
An international team of scientists led by Dr. Matthias G. Wacker developed an apparatus to analyse the release behavior of micro and nanodispersions under standardised conditions. This so-called dispersion releaser technology uses a dialysis cell that can be combined with compendial equipment. It can be easily integrated in formulation development and quality control. Besides the efficient separation of the drug substance and a reduced sedimentation during the dialysis process, the dispersion releaser ensures compliance with international standards – although there is a lack of consistent and reliable standards so far to test micro and nanodispersions. It also makes measurements under physiological conditions possible and therefore allows predictions for subsequent therapy. First prototypes of the new system have been tested successfully with several drug substances.